Ex vivo occupancy of gamma-secretase inhibitors correlates with brain beta-amyloid peptide reduction in Tg2576 mice.

Goldstein, Margi E

Ex vivo occupancy of gamma-secretase inhibitors correlates with brain beta-amyloid peptide reduction in Tg2576 mice. [electronic resource] - The Journal of pharmacology and experimental therapeutics Oct 2007 - 102-8 p. digital

Publication Type: Journal Article

0022-3565

10.1124/jpet.107.125492 doi


Amyloid Precursor Protein Secretases--antagonists & inhibitors
Amyloid beta-Protein Precursor--biosynthesis
Animals
Binding Sites
Brain--drug effects
Dose-Response Relationship, Drug
Enzyme Inhibitors--chemistry
Ligands
Mice
Mice, Transgenic
Molecular Structure
Radioligand Assay
Time Factors