Endothelial nitric oxide synthase plays an obligatory role in the late phase of ischemic preconditioning by activating the protein kinase C epsilon p44/42 mitogen-activated protein kinase pSer-signal transducers and activators of transcription1/3 pathway.

Xuan, Yu-Ting

Endothelial nitric oxide synthase plays an obligatory role in the late phase of ischemic preconditioning by activating the protein kinase C epsilon p44/42 mitogen-activated protein kinase pSer-signal transducers and activators of transcription1/3 pathway. [electronic resource] - Circulation Jul 2007 - 535-44 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural

1524-4539

10.1161/CIRCULATIONAHA.107.689471 doi


Adaptation, Physiological--physiology
Animals
Cyclooxygenase 2--biosynthesis
DNA--genetics
Enzyme Activation--drug effects
Enzyme Induction--drug effects
Hypertension--complications
Ischemic Preconditioning, Myocardial
MAP Kinase Kinase Kinase 1--physiology
MAP Kinase Kinase Kinase 2--physiology
Mice
Mice, Inbred C57BL
Mice, Knockout
Mice, Mutant Strains
Mitogen-Activated Protein Kinase 1--physiology
Mitogen-Activated Protein Kinase 3--physiology
Myocardial Infarction--pathology
Myocardial Reperfusion Injury--physiopathology
Nitric Oxide--physiology
Nitric Oxide Donors--pharmacology
Nitric Oxide Synthase Type II--deficiency
Nitric Oxide Synthase Type III
Phosphorylation--drug effects
Protein Kinase C-epsilon--physiology
Protein Processing, Post-Translational--drug effects
STAT1 Transcription Factor--physiology
STAT3 Transcription Factor--physiology
Signal Transduction--drug effects
Specific Pathogen-Free Organisms
Stress, Physiological--physiopathology
Time Factors
Triazenes--pharmacology