Hypoxia-inducible factor 1alpha is regulated by the mammalian target of rapamycin (mTOR) via an mTOR signaling motif.

Land, Stephen C

Hypoxia-inducible factor 1alpha is regulated by the mammalian target of rapamycin (mTOR) via an mTOR signaling motif. [electronic resource] - The Journal of biological chemistry Jul 2007 - 20534-43 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0021-9258

10.1074/jbc.M611782200 doi


Amino Acid Motifs--genetics
Animals
Antibiotics, Antineoplastic--pharmacology
Cell Hypoxia--drug effects
Cell Line, Tumor
Guanine Nucleotides--metabolism
Humans
Hypoxia-Inducible Factor 1, alpha Subunit--genetics
Mice
Monomeric GTP-Binding Proteins--genetics
Mutation, Missense
Neoplasms--drug therapy
Neovascularization, Pathologic--drug therapy
Neuropeptides--genetics
Protein Binding--drug effects
Protein Kinases--genetics
Protein Structure, Tertiary--drug effects
Ras Homolog Enriched in Brain Protein
Signal Transduction--drug effects
Sirolimus--pharmacology
TOR Serine-Threonine Kinases
Tuberous Sclerosis Complex 2 Protein
Tumor Suppressor Proteins--genetics
Vascular Endothelial Growth Factor A--genetics
Von Hippel-Lindau Tumor Suppressor Protein--genetics
p300-CBP Transcription Factors--genetics