5-HT acts on nociceptive primary afferents through an indirect mechanism to induce hyperalgesia in the subcutaneous tissue.

Oliveira, M C G

5-HT acts on nociceptive primary afferents through an indirect mechanism to induce hyperalgesia in the subcutaneous tissue. [electronic resource] - Neuroscience Mar 2007 - 708-14 p. digital

Publication Type: Journal Article

0306-4522

10.1016/j.neuroscience.2006.12.021 doi


Adrenergic beta-2 Receptor Agonists
Adrenergic beta-2 Receptor Antagonists
Adrenergic beta-Antagonists--pharmacology
Afferent Pathways--drug effects
Animals
Chemotaxis, Leukocyte--drug effects
Cyclooxygenase Inhibitors--pharmacology
Dose-Response Relationship, Drug
Hyperalgesia--chemically induced
Male
Nociceptors--drug effects
Norepinephrine--metabolism
Pain Measurement--drug effects
Pain Threshold--drug effects
Prostaglandins--metabolism
Rats
Rats, Wistar
Receptors, Adrenergic, beta-2--metabolism
Receptors, Serotonin, 5-HT3--metabolism
Selectins--drug effects
Sensory Receptor Cells--drug effects
Serotonin--metabolism
Serotonin 5-HT3 Receptor Antagonists
Serotonin Antagonists--pharmacology
Skin--innervation
Sympathetic Fibers, Postganglionic--drug effects