effect of OATP1B transporter inhibition on the pharmacokinetics of atorvastatin in healthy volunteers.

Lau, Y Y

effect of OATP1B transporter inhibition on the pharmacokinetics of atorvastatin in healthy volunteers. [electronic resource] - Clinical pharmacology and therapeutics Feb 2007 - 194-204 p. digital

Publication Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural

0009-9236

10.1038/sj.clpt.6100038 doi


Administration, Oral
Adolescent
Adult
Area Under Curve
Atorvastatin
Bile--chemistry
Binding, Competitive
Biological Transport--drug effects
Cell Line
Cross-Over Studies
Enzyme Inhibitors--administration & dosage
Female
Heptanoic Acids--administration & dosage
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors--administration & dosage
Infusions, Intravenous
Liver--drug effects
Liver-Specific Organic Anion Transporter 1
Male
Middle Aged
Organic Anion Transporters--antagonists & inhibitors
Pyrroles--administration & dosage
Rifampin--administration & dosage
Substrate Specificity
Tablets
Transfection