Proteasome inhibition induces glutathione synthesis and protects cells from oxidative stress: relevance to Parkinson disease.

Yamamoto, Noriyuki

Proteasome inhibition induces glutathione synthesis and protects cells from oxidative stress: relevance to Parkinson disease. [electronic resource] - The Journal of biological chemistry Feb 2007 - 4364-4372 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0021-9258

10.1074/jbc.M603712200 doi


Acetylcysteine--analogs & derivatives
Active Transport, Cell Nucleus--drug effects
Adrenergic Agents--toxicity
Animals
Cell Nucleus--metabolism
Cysteine Proteinase Inhibitors--pharmacology
Dose-Response Relationship, Drug
Glutathione--biosynthesis
Hydrogen Peroxide--toxicity
Imidazoles--pharmacology
Models, Biological
NF-E2 Transcription Factor--metabolism
Oxidants--toxicity
Oxidative Stress--drug effects
Oxidopamine--toxicity
PC12 Cells
Parkinson Disease--metabolism
Proteasome Endopeptidase Complex--metabolism
Proteasome Inhibitors
Pyridines--pharmacology
Rats
Reactive Oxygen Species--metabolism
Ubiquitin--metabolism
p38 Mitogen-Activated Protein Kinases--antagonists & inhibitors