AICAR potentiates ROS production induced by chronic high glucose: roles of AMPK in pancreatic beta-cell apoptosis.

Kim, Won-Ho

AICAR potentiates ROS production induced by chronic high glucose: roles of AMPK in pancreatic beta-cell apoptosis. [electronic resource] - Cellular signalling Apr 2007 - 791-805 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0898-6568

10.1016/j.cellsig.2006.10.004 doi


AMP-Activated Protein Kinases
Aminoimidazole Carboxamide--analogs & derivatives
Animals
Apoptosis--drug effects
Cell Line, Transformed
Down-Regulation--drug effects
Enzyme Activation--drug effects
Gene Expression--drug effects
Glucokinase--genetics
Glucose--pharmacology
Insulin-Secreting Cells--cytology
Membrane Potential, Mitochondrial--drug effects
Mice
Multienzyme Complexes--metabolism
Protein Serine-Threonine Kinases--metabolism
Proteins--metabolism
Rats
Reactive Oxygen Species--metabolism
Ribonucleotides--pharmacology