Synthetic cryptolepine inhibits DNA binding of NF-kappaB.
Olajide, Olumayokun A
Synthetic cryptolepine inhibits DNA binding of NF-kappaB. [electronic resource] - Bioorganic & medicinal chemistry Jan 2007 - 43-9 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
0968-0896
10.1016/j.bmc.2006.10.018 doi
Alkaloids--chemical synthesis
Animals
Anti-Inflammatory Agents--chemical synthesis
Binding Sites
Binding, Competitive--drug effects
Cell Line
Cells, Cultured
Cryptolepis--chemistry
DNA--drug effects
Dose-Response Relationship, Drug
Drug Evaluation, Preclinical
Humans
Indole Alkaloids
Indoles--chemical synthesis
Lipopolysaccharides--antagonists & inhibitors
Macrophages--cytology
Mice
NF-kappa B--antagonists & inhibitors
Nitric Oxide--antagonists & inhibitors
Quinolines--chemical synthesis
Structure-Activity Relationship
Transcription, Genetic--drug effects
Synthetic cryptolepine inhibits DNA binding of NF-kappaB. [electronic resource] - Bioorganic & medicinal chemistry Jan 2007 - 43-9 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
0968-0896
10.1016/j.bmc.2006.10.018 doi
Alkaloids--chemical synthesis
Animals
Anti-Inflammatory Agents--chemical synthesis
Binding Sites
Binding, Competitive--drug effects
Cell Line
Cells, Cultured
Cryptolepis--chemistry
DNA--drug effects
Dose-Response Relationship, Drug
Drug Evaluation, Preclinical
Humans
Indole Alkaloids
Indoles--chemical synthesis
Lipopolysaccharides--antagonists & inhibitors
Macrophages--cytology
Mice
NF-kappa B--antagonists & inhibitors
Nitric Oxide--antagonists & inhibitors
Quinolines--chemical synthesis
Structure-Activity Relationship
Transcription, Genetic--drug effects