FLT3 K663Q is a novel AML-associated oncogenic kinase: Determination of biochemical properties and sensitivity to Sunitinib (SU11248).

Schittenhelm, M M

FLT3 K663Q is a novel AML-associated oncogenic kinase: Determination of biochemical properties and sensitivity to Sunitinib (SU11248). [electronic resource] - Leukemia Nov 2006 - 2008-14 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

0887-6924

10.1038/sj.leu.2404374 doi


Acute Disease
Amino Acid Sequence
Amino Acid Substitution
Animals
Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Base Sequence
Cell Division--drug effects
Cell Line, Tumor
Humans
Indoles--pharmacology
Leukemia, Myeloid--drug therapy
Mice
Mice, Inbred BALB C
Mice, Nude
Mutagenesis, Site-Directed
Neoplasm Transplantation
Point Mutation
Pyrroles--pharmacology
Sunitinib
fms-Like Tyrosine Kinase 3--genetics