The anxioselective agent 7-(2-chloropyridin-4-yl)pyrazolo-[1,5-a]-pyrimidin-3-yl](pyridin-2-yl)methanone (DOV 51892) is more efficacious than diazepam at enhancing GABA-gated currents at alpha1 subunit-containing GABAA receptors.
Popik, Piotr
The anxioselective agent 7-(2-chloropyridin-4-yl)pyrazolo-[1,5-a]-pyrimidin-3-yl](pyridin-2-yl)methanone (DOV 51892) is more efficacious than diazepam at enhancing GABA-gated currents at alpha1 subunit-containing GABAA receptors. [electronic resource] - The Journal of pharmacology and experimental therapeutics Dec 2006 - 1244-52 p. digital
Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
0022-3565
10.1124/jpet.106.107201 doi
Animals
Anti-Anxiety Agents--chemical synthesis
Ataxia--chemically induced
Chloride Channels--drug effects
Diazepam--pharmacology
Dose-Response Relationship, Drug
Exploratory Behavior--drug effects
Hand Strength--physiology
Hypnotics and Sedatives--pharmacology
Male
Motor Activity--drug effects
Muscle Relaxation--drug effects
Oocytes--metabolism
Postural Balance--drug effects
Pyrazoles--chemical synthesis
Pyridines--chemical synthesis
Radioligand Assay
Rats
Rats, Sprague-Dawley
Rats, Wistar
Receptors, GABA-A--drug effects
Xenopus laevis
gamma-Aminobutyric Acid--physiology
The anxioselective agent 7-(2-chloropyridin-4-yl)pyrazolo-[1,5-a]-pyrimidin-3-yl](pyridin-2-yl)methanone (DOV 51892) is more efficacious than diazepam at enhancing GABA-gated currents at alpha1 subunit-containing GABAA receptors. [electronic resource] - The Journal of pharmacology and experimental therapeutics Dec 2006 - 1244-52 p. digital
Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
0022-3565
10.1124/jpet.106.107201 doi
Animals
Anti-Anxiety Agents--chemical synthesis
Ataxia--chemically induced
Chloride Channels--drug effects
Diazepam--pharmacology
Dose-Response Relationship, Drug
Exploratory Behavior--drug effects
Hand Strength--physiology
Hypnotics and Sedatives--pharmacology
Male
Motor Activity--drug effects
Muscle Relaxation--drug effects
Oocytes--metabolism
Postural Balance--drug effects
Pyrazoles--chemical synthesis
Pyridines--chemical synthesis
Radioligand Assay
Rats
Rats, Sprague-Dawley
Rats, Wistar
Receptors, GABA-A--drug effects
Xenopus laevis
gamma-Aminobutyric Acid--physiology