Impact of EGFR point mutations on the sensitivity to gefitinib: insights from comparative structural analyses and molecular dynamics simulations.

Liu, Bing

Impact of EGFR point mutations on the sensitivity to gefitinib: insights from comparative structural analyses and molecular dynamics simulations. [electronic resource] - Proteins Nov 2006 - 331-46 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1097-0134

10.1002/prot.21111 doi


Adenosine Triphosphate--chemistry
Binding Sites
Computational Biology
Computer Simulation
Crystallography, X-Ray
ErbB Receptors--chemistry
Gefitinib
Ligands
Models, Molecular
Point Mutation--genetics
Protein Structure, Secondary
Protein Structure, Tertiary
Proto-Oncogene Proteins c-abl--chemistry
Quinazolines--chemistry
Static Electricity