Aripiprazole and its human metabolite are partial agonists at the human dopamine D2 receptor, but the rodent metabolite displays antagonist properties.

Wood, Martyn D

Aripiprazole and its human metabolite are partial agonists at the human dopamine D2 receptor, but the rodent metabolite displays antagonist properties. [electronic resource] - European journal of pharmacology Sep 2006 - 88-94 p. digital

Publication Type: Comparative Study; Journal Article

0014-2999

10.1016/j.ejphar.2006.07.008 doi


Amphetamine
Animals
Antipsychotic Agents--metabolism
Aripiprazole
Behavior, Animal--drug effects
Binding, Competitive
Biotransformation
CHO Cells
Catalepsy--chemically induced
Cricetinae
Cricetulus
Dopamine D2 Receptor Antagonists
Dyskinesia, Drug-Induced--etiology
Guanosine 5'-O-(3-Thiotriphosphate)--metabolism
HeLa Cells
Humans
Male
Motor Activity--drug effects
Oxidopamine
Piperazines--metabolism
Quinolones--metabolism
Radioligand Assay
Rats
Rats, Sprague-Dawley
Receptors, Dopamine D2--agonists
Species Specificity
Transfection