Circulating interleukin-6 induces fever through a STAT3-linked activation of COX-2 in the brain.
Rummel, Christoph
Circulating interleukin-6 induces fever through a STAT3-linked activation of COX-2 in the brain. [electronic resource] - American journal of physiology. Regulatory, integrative and comparative physiology Nov 2006 - R1316-26 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
0363-6119
10.1152/ajpregu.00301.2006 doi
Animals
Body Temperature--drug effects
Brain--metabolism
Cyclooxygenase 2--genetics
Endothelial Cells--metabolism
Fever--physiopathology
Gene Expression Regulation--physiology
Immune Sera--immunology
Interleukin-6--blood
Lipopolysaccharides--adverse effects
Male
NF-kappa B--genetics
Pyrogens--blood
RNA, Messenger--genetics
Rats
Rats, Sprague-Dawley
STAT3 Transcription Factor--genetics
Suppressor of Cytokine Signaling 3 Protein
Suppressor of Cytokine Signaling Proteins--genetics
Circulating interleukin-6 induces fever through a STAT3-linked activation of COX-2 in the brain. [electronic resource] - American journal of physiology. Regulatory, integrative and comparative physiology Nov 2006 - R1316-26 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
0363-6119
10.1152/ajpregu.00301.2006 doi
Animals
Body Temperature--drug effects
Brain--metabolism
Cyclooxygenase 2--genetics
Endothelial Cells--metabolism
Fever--physiopathology
Gene Expression Regulation--physiology
Immune Sera--immunology
Interleukin-6--blood
Lipopolysaccharides--adverse effects
Male
NF-kappa B--genetics
Pyrogens--blood
RNA, Messenger--genetics
Rats
Rats, Sprague-Dawley
STAT3 Transcription Factor--genetics
Suppressor of Cytokine Signaling 3 Protein
Suppressor of Cytokine Signaling Proteins--genetics