JAK1 N-terminus binds to conserved Box 1 and Box 2 motifs of cytokine receptor common beta subunit but signal activation requires JAK1 C-terminus.

Huang, Huei-Mei

JAK1 N-terminus binds to conserved Box 1 and Box 2 motifs of cytokine receptor common beta subunit but signal activation requires JAK1 C-terminus. [electronic resource] - Journal of cellular biochemistry Nov 2006 - 1078-84 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0730-2312

10.1002/jcb.20942 doi


Amino Acid Motifs
Animals
Conserved Sequence
Cross-Linking Reagents
Cytokine Receptor Common beta Subunit--chemistry
Humans
Interleukin-3 Receptor alpha Subunit--metabolism
Janus Kinase 1--chemistry
Janus Kinase 2--metabolism
Mice
Protein Binding
Protein Structure, Tertiary
Signal Transduction