IMP dehydrogenase inhibitor mycophenolate mofetil induces caspase-dependent apoptosis and cell cycle inhibition in multiple myeloma cells.

Takebe, Naoko

IMP dehydrogenase inhibitor mycophenolate mofetil induces caspase-dependent apoptosis and cell cycle inhibition in multiple myeloma cells. [electronic resource] - Molecular cancer therapeutics Feb 2006 - 457-66 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1535-7163

10.1158/1535-7163.MCT-05-0340 doi


Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Caspases--metabolism
Cell Cycle--drug effects
Cell Line, Tumor
Cyclin-Dependent Kinase Inhibitor p21--metabolism
Guanosine--pharmacology
Humans
IMP Dehydrogenase--antagonists & inhibitors
Multiple Myeloma--enzymology
Mycophenolic Acid--analogs & derivatives
Phosphorylation--drug effects
Proto-Oncogene Proteins c-bcl-2--metabolism
STAT3 Transcription Factor--metabolism