Synthesis and evaluation of succinoyl-caprolactam gamma-secretase inhibitors.

Thompson, Lorin A

Synthesis and evaluation of succinoyl-caprolactam gamma-secretase inhibitors. [electronic resource] - Bioorganic & medicinal chemistry letters May 2006 - 2357-63 p. digital

Publication Type: Journal Article

0960-894X

10.1016/j.bmcl.2006.01.055 doi


Alzheimer Disease--drug therapy
Amyloid Precursor Protein Secretases
Animals
Aspartic Acid Endopeptidases
Caprolactam--analogs & derivatives
Cell Line
Dogs
Drug Design
Drug Evaluation, Preclinical
Endopeptidases--chemistry
Enzyme Inhibitors--chemical synthesis
Humans
Molecular Conformation
Stereoisomerism
Structure-Activity Relationship
Succinates--chemistry