Mechanisms of antiplatelet activity of PC-09, a newly synthesized pyridazinone derivative.

Cherng, Shiou-Chi

Mechanisms of antiplatelet activity of PC-09, a newly synthesized pyridazinone derivative. [electronic resource] - European journal of pharmacology Feb 2006 - 32-7 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0014-2999

10.1016/j.ejphar.2005.12.022 doi


1-Methyl-3-isobutylxanthine--pharmacology
3',5'-Cyclic-AMP Phosphodiesterases--antagonists & inhibitors
Adenosine Triphosphate--metabolism
Alprostadil--pharmacology
Animals
Arachidonic Acid--pharmacology
Blood Platelets--drug effects
Calcium--metabolism
Collagen--pharmacology
Cyclic AMP--metabolism
Cyclic GMP--metabolism
Dose-Response Relationship, Drug
Imidazoles--pharmacology
Indomethacin--pharmacology
Naphthalenes--chemistry
Phosphodiesterase Inhibitors--pharmacology
Platelet Aggregation--drug effects
Platelet Aggregation Inhibitors--pharmacology
Platelet Glycoprotein GPIIb-IIIa Complex--biosynthesis
Pyridazines--chemistry
Rabbits
Thrombin--pharmacology
Thromboxane A2--biosynthesis
Thromboxane-A Synthase--metabolism