Pharmacokinetics and pharmacodynamics of the vasopeptidase inhibitor AVE7688 in humans.

Azizi, Michel

Pharmacokinetics and pharmacodynamics of the vasopeptidase inhibitor AVE7688 in humans. [electronic resource] - Clinical pharmacology and therapeutics Jan 2006 - 49-61 p. digital

Publication Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

0009-9236

10.1016/j.clpt.2005.09.011 doi


Adolescent
Adult
Aldosterone--urine
Angiotensin II Type 1 Receptor Blockers--pharmacology
Angiotensin-Converting Enzyme Inhibitors--pharmacokinetics
Atrial Natriuretic Factor--urine
Biotransformation
Biphenyl Compounds--pharmacology
Cross-Over Studies
Cyclic GMP--urine
Dose-Response Relationship, Drug
Heterocyclic Compounds, 3-Ring--pharmacokinetics
Humans
Irbesartan
Male
Natriuresis--drug effects
Oligopeptides--urine
Peptidyl-Dipeptidase A--blood
Protease Inhibitors--pharmacokinetics
Ramipril--pharmacology
Renin--blood
Renin-Angiotensin System--drug effects
Single-Blind Method
Tetrazoles--pharmacology