Depletion of securin increases arsenite-induced chromosome instability and apoptosis via a p53-independent pathway.

Chao, Jui-I

Depletion of securin increases arsenite-induced chromosome instability and apoptosis via a p53-independent pathway. [electronic resource] - Toxicological sciences : an official journal of the Society of Toxicology Mar 2006 - 73-86 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1096-6080

10.1093/toxsci/kfj070 doi


Animals
Apoptosis--drug effects
Arsenites--toxicity
CDC2 Protein Kinase--antagonists & inhibitors
Carrier Proteins--metabolism
Cell Line, Tumor
Cell Survival--drug effects
Colorectal Neoplasms--drug therapy
Cyclin B--metabolism
Cyclin B1
Dose-Response Relationship, Drug
Endothelium, Vascular--drug effects
Enzyme Inhibitors--toxicity
Epithelial Cells--drug effects
Mice
Mitosis--drug effects
Securin
Sister Chromatid Exchange--drug effects
Sodium Compounds--toxicity
Tumor Suppressor Protein p53--metabolism