Macrocyclic peptidomimetic inhibitors of beta-secretase (BACE): first X-ray structure of a macrocyclic peptidomimetic-BACE complex.

Rojo, Isabel

Macrocyclic peptidomimetic inhibitors of beta-secretase (BACE): first X-ray structure of a macrocyclic peptidomimetic-BACE complex. [electronic resource] - Bioorganic & medicinal chemistry letters Jan 2006 - 191-5 p. digital

Publication Type: Journal Article

0960-894X

10.1016/j.bmcl.2005.09.003 doi


Alzheimer Disease--drug therapy
Amyloid Precursor Protein Secretases
Amyloid beta-Protein Precursor--chemistry
Animals
Aspartic Acid Endopeptidases
Cell Line
Chemistry, Pharmaceutical--methods
Crystallography, X-Ray--methods
Drug Design
Endopeptidases--chemistry
Humans
Kinetics
Models, Chemical
Models, Molecular
Protein Conformation
Protein Structure, Tertiary