Identification and initial evaluation of 4-N-aryl-[1,4]diazepane ureas as potent CXCR3 antagonists.

Cole, Andrew G

Identification and initial evaluation of 4-N-aryl-[1,4]diazepane ureas as potent CXCR3 antagonists. [electronic resource] - Bioorganic & medicinal chemistry letters Jan 2006 - 200-3 p. digital

Publication Type: Journal Article

0960-894X

10.1016/j.bmcl.2005.09.020 doi


Calcium--metabolism
Cell Line
Chemistry, Pharmaceutical--methods
Chemokine CXCL11
Chemokines, CXC--chemistry
Chemotaxis
Dose-Response Relationship, Drug
Drug Design
Drug Evaluation, Preclinical
Electrons
Humans
Inflammation
Inhibitory Concentration 50
Models, Chemical
Receptors, CXCR3
Receptors, Chemokine--antagonists & inhibitors
Receptors, G-Protein-Coupled--metabolism
Recombinant Proteins--chemistry
Stereoisomerism
T-Lymphocytes--cytology
Urea--chemistry