Design and synthesis of tricyclic imidazo[4,5-b]pyridin-2-ones as corticotropin-releasing factor-1 antagonists.

Guo, Zhiqiang

Design and synthesis of tricyclic imidazo[4,5-b]pyridin-2-ones as corticotropin-releasing factor-1 antagonists. [electronic resource] - Journal of medicinal chemistry Aug 2005 - 5104-7 p. digital

Publication Type: Journal Article

0022-2623

10.1021/jm050384+ doi


Administration, Oral
Adrenocorticotropic Hormone--blood
Animals
Blood-Brain Barrier--metabolism
CHO Cells
Corticotropin-Releasing Hormone--pharmacology
Cricetinae
Cricetulus
Cyclic AMP--antagonists & inhibitors
Drug Design
Heterocyclic Compounds, 3-Ring--chemical synthesis
Humans
Imidazoles--chemical synthesis
Injections, Intravenous
Male
Pyridines--chemical synthesis
Radioligand Assay
Rats
Rats, Sprague-Dawley
Receptors, Corticotropin-Releasing Hormone--antagonists & inhibitors
Stereoisomerism
Structure-Activity Relationship
CRF Receptor, Type 1