Hepatic gene expression changes in mouse models with liver-specific deletion or global suppression of the NADPH-cytochrome P450 reductase gene. Mechanistic implications for the regulation of microsomal cytochrome P450 and the fatty liver phenotype.
Weng, Yan
Hepatic gene expression changes in mouse models with liver-specific deletion or global suppression of the NADPH-cytochrome P450 reductase gene. Mechanistic implications for the regulation of microsomal cytochrome P450 and the fatty liver phenotype. [electronic resource] - The Journal of biological chemistry Sep 2005 - 31686-98 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
0021-9258
10.1074/jbc.M504447200 doi
Animals
Cholesterol--biosynthesis
Cytochrome P-450 Enzyme System--metabolism
Enzyme Repression
Fatty Acids--biosynthesis
Fatty Liver--enzymology
Gene Deletion
Gene Expression Profiling
Mice
Mice, Knockout
Microsomes, Liver--enzymology
NADPH-Ferrihemoprotein Reductase--biosynthesis
Oligonucleotide Array Sequence Analysis
Phenotype
Hepatic gene expression changes in mouse models with liver-specific deletion or global suppression of the NADPH-cytochrome P450 reductase gene. Mechanistic implications for the regulation of microsomal cytochrome P450 and the fatty liver phenotype. [electronic resource] - The Journal of biological chemistry Sep 2005 - 31686-98 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
0021-9258
10.1074/jbc.M504447200 doi
Animals
Cholesterol--biosynthesis
Cytochrome P-450 Enzyme System--metabolism
Enzyme Repression
Fatty Acids--biosynthesis
Fatty Liver--enzymology
Gene Deletion
Gene Expression Profiling
Mice
Mice, Knockout
Microsomes, Liver--enzymology
NADPH-Ferrihemoprotein Reductase--biosynthesis
Oligonucleotide Array Sequence Analysis
Phenotype