Role of PI3K/Akt and MEK/ERK signaling pathways in sulforaphane- and erucin-induced phase II enzymes and MRP2 transcription, G2/M arrest and cell death in Caco-2 cells.

Jakubíková, Jana

Role of PI3K/Akt and MEK/ERK signaling pathways in sulforaphane- and erucin-induced phase II enzymes and MRP2 transcription, G2/M arrest and cell death in Caco-2 cells. [electronic resource] - Biochemical pharmacology Jun 2005 - 1543-52 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

0006-2952

10.1016/j.bcp.2005.03.015 doi


Caco-2 Cells
Cell Death--drug effects
Cell Division--drug effects
Enzyme Induction--drug effects
Enzyme Inhibitors--pharmacology
Extracellular Signal-Regulated MAP Kinases--physiology
G2 Phase--drug effects
Glucuronosyltransferase--biosynthesis
Humans
Isothiocyanates
MAP Kinase Kinase Kinases--physiology
MAP Kinase Signaling System--drug effects
Membrane Transport Proteins--genetics
Multidrug Resistance-Associated Protein 2
Multidrug Resistance-Associated Proteins--genetics
NAD(P)H Dehydrogenase (Quinone)--biosynthesis
Phosphatidylinositol 3-Kinases--physiology
Protein Serine-Threonine Kinases--physiology
Proto-Oncogene Proteins--physiology
Proto-Oncogene Proteins c-akt
Sulfides--pharmacology
Sulfoxides
Thiocyanates--pharmacology
Transcription, Genetic--drug effects