Disruption of fibroblast growth factor signal pathway inhibits the growth of synovial sarcomas: potential application of signal inhibitors to molecular target therapy.

Ishibe, Tatsuya

Disruption of fibroblast growth factor signal pathway inhibits the growth of synovial sarcomas: potential application of signal inhibitors to molecular target therapy. [electronic resource] - Clinical cancer research : an official journal of the American Association for Cancer Research Apr 2005 - 2702-12 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1078-0432

10.1158/1078-0432.CCR-04-2057 doi


Animals
Cell Line, Tumor
Cell Proliferation--drug effects
Dose-Response Relationship, Drug
Enzyme Activation--drug effects
Female
Fibroblast Growth Factors--genetics
Gene Expression Regulation, Neoplastic
Humans
Male
Mice
Mice, Inbred BALB C
Mice, Nude
Mitogen-Activated Protein Kinase 1--metabolism
Mitogen-Activated Protein Kinase 3--metabolism
Mitogen-Activated Protein Kinases--metabolism
Phosphorylation--drug effects
Protein Isoforms--genetics
Pyrimidines--pharmacology
Pyrroles--pharmacology
RNA, Messenger--genetics
Receptors, Fibroblast Growth Factor--antagonists & inhibitors
Recombinant Proteins--pharmacology
Reverse Transcriptase Polymerase Chain Reaction
Sarcoma, Synovial--genetics
Signal Transduction--drug effects
Urea--analogs & derivatives
Xenograft Model Antitumor Assays