FLT3-ITD and tyrosine kinase domain mutants induce 2 distinct phenotypes in a murine bone marrow transplantation model.

Grundler, Rebekka

FLT3-ITD and tyrosine kinase domain mutants induce 2 distinct phenotypes in a murine bone marrow transplantation model. [electronic resource] - Blood Jun 2005 - 4792-9 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0006-4971

10.1182/blood-2004-11-4430 doi


Animals
Blotting, Southern
Bone Marrow Cells--cytology
Bone Marrow Transplantation
Cell Separation
DNA, Complementary--metabolism
DNA-Binding Proteins--metabolism
Flow Cytometry
Green Fluorescent Proteins--metabolism
Immunoblotting
Immunophenotyping
Immunoprecipitation
Leukemia, Myeloid, Acute--genetics
Mice
Milk Proteins--metabolism
Mutation
Myeloproliferative Disorders--genetics
Phenotype
Point Mutation
Precursor Cell Lymphoblastic Leukemia-Lymphoma--genetics
Protein Structure, Tertiary
Protein-Tyrosine Kinases--chemistry
Proto-Oncogene Proteins--chemistry
Receptor Protein-Tyrosine Kinases--chemistry
Recombinant Proteins--chemistry
Retroviridae--genetics
STAT5 Transcription Factor
Signal Transduction
Splenomegaly--pathology
Trans-Activators--metabolism
Treatment Outcome
fms-Like Tyrosine Kinase 3