Effect of 4-(5-chloro-2-hydroxyphenyl)-3-(2-hydroxyethyl)-6-(trifluoromethyl)-quinolin-2(1H)-one (BMS-223131), a novel opener of large conductance Ca2+-activated K+ (maxi-K) channels on normal and stress-aggravated colonic motility and visceral nociception.

Sivarao, Digavalli V

Effect of 4-(5-chloro-2-hydroxyphenyl)-3-(2-hydroxyethyl)-6-(trifluoromethyl)-quinolin-2(1H)-one (BMS-223131), a novel opener of large conductance Ca2+-activated K+ (maxi-K) channels on normal and stress-aggravated colonic motility and visceral nociception. [electronic resource] - The Journal of pharmacology and experimental therapeutics May 2005 - 840-7 p. digital

Publication Type: Comparative Study; Journal Article

0022-3565

10.1124/jpet.104.079285 doi


Animals
Blood Pressure--drug effects
Colon--drug effects
Dose-Response Relationship, Drug
Female
Gastrointestinal Motility--drug effects
Ion Channel Gating--drug effects
Large-Conductance Calcium-Activated Potassium Channels
Pain Measurement--drug effects
Potassium Channels, Calcium-Activated--agonists
Quinolines--administration & dosage
Quinolones--administration & dosage
Rats
Rats, Wistar
Stress, Physiological--drug therapy
Viscera--drug effects