Role of the interactions between the active site base and the substrate Schiff base in amine oxidase catalysis. Evidence from structural and spectroscopic studies of the 2-hydrazinopyridine adduct of Escherichia coli amine oxidase.

Mure, Minae

Role of the interactions between the active site base and the substrate Schiff base in amine oxidase catalysis. Evidence from structural and spectroscopic studies of the 2-hydrazinopyridine adduct of Escherichia coli amine oxidase. [electronic resource] - Biochemistry Feb 2005 - 1568-82 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

0006-2960

10.1021/bi047988k doi


Amine Oxidase (Copper-Containing)--antagonists & inhibitors
Binding Sites--genetics
Catalysis
Crystallography, X-Ray
Enzyme Inhibitors--chemistry
Enzyme Stability--genetics
Escherichia coli Proteins--antagonists & inhibitors
Hydrogen-Ion Concentration
Kinetics
Mutagenesis, Site-Directed
Nuclear Magnetic Resonance, Biomolecular
Pyridones--chemistry
Schiff Bases--metabolism
Solutions
Spectrophotometry, Ultraviolet
Spectrum Analysis, Raman
Substrate Specificity--genetics
Titrimetry