Possible involvement of pregnane X receptor-enhanced CYP24 expression in drug-induced osteomalacia.

Pascussi, Jean Marc

Possible involvement of pregnane X receptor-enhanced CYP24 expression in drug-induced osteomalacia. [electronic resource] - The Journal of clinical investigation Jan 2005 - 177-86 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0021-9738

10.1172/JCI21867 doi


Animals
Cells, Cultured
Cytochrome P-450 Enzyme System--biosynthesis
Gene Expression Regulation--drug effects
Hepatocytes--drug effects
Humans
Mice
Molecular Sequence Data
Mutation--genetics
Osteomalacia--chemically induced
Pregnane X Receptor
Promoter Regions, Genetic--genetics
RNA, Messenger--genetics
Receptors, Cytoplasmic and Nuclear--agonists
Receptors, Steroid--agonists
Rifampin--pharmacology
Steroid Hydroxylases--biosynthesis
Transcriptional Activation--genetics
Vitamin D Response Element--genetics
Vitamin D3 24-Hydroxylase