Functional overexpression of gamma-secretase reveals protease-independent trafficking functions and a critical role of lipids for protease activity.

Wrigley, Jonathan D J

Functional overexpression of gamma-secretase reveals protease-independent trafficking functions and a critical role of lipids for protease activity. [electronic resource] - The Journal of biological chemistry Apr 2005 - 12523-35 p. digital

Publication Type: Journal Article

0021-9258

10.1074/jbc.M413086200 doi


Amyloid Precursor Protein Secretases
Amyloid beta-Protein Precursor--metabolism
Aspartic Acid Endopeptidases
Binding Sites
Blotting, Western
Brain--metabolism
Catalysis
Cell Line
Cell Membrane--metabolism
Cell-Free System--metabolism
Chromatography
Culture Media--metabolism
Culture Media, Conditioned--pharmacology
DNA, Complementary--metabolism
Dimerization
Endopeptidases--biosynthesis
Golgi Apparatus--metabolism
Humans
Immunohistochemistry
Lipid Metabolism
Membrane Glycoproteins--metabolism
Peptide Hydrolases--metabolism
Peptides--chemistry
Protein Structure, Tertiary
Time Factors