Simvastatin induces proliferation inhibition and apoptosis in C6 glioma cells via c-jun N-terminal kinase.

Koyuturk, Meral

Simvastatin induces proliferation inhibition and apoptosis in C6 glioma cells via c-jun N-terminal kinase. [electronic resource] - Neuroscience letters Nov 2004 - 212-7 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

0304-3940

10.1016/j.neulet.2004.08.020 doi


Activating Transcription Factor 2
Animals
Apoptosis--drug effects
Cell Line, Tumor--cytology
Cell Proliferation--drug effects
Cyclic AMP Response Element-Binding Protein--metabolism
DNA Fragmentation--drug effects
Glioma
Hydroxymethylglutaryl-CoA Reductase Inhibitors--pharmacology
Immunohistochemistry--methods
JNK Mitogen-Activated Protein Kinases--metabolism
Mice
Mitogen-Activated Protein Kinase 3--metabolism
Phosphorylation--drug effects
Proliferating Cell Nuclear Antigen--metabolism
Protein Serine-Threonine Kinases--metabolism
Proto-Oncogene Proteins--metabolism
Proto-Oncogene Proteins c-akt
Proto-Oncogene Proteins c-jun--metabolism
Simvastatin--pharmacology
Time Factors
Transcription Factors--metabolism