SPRY2 is an inhibitor of the ras/extracellular signal-regulated kinase pathway in melanocytes and melanoma cells with wild-type BRAF but not with the V599E mutant.

Tsavachidou, Dimitra

SPRY2 is an inhibitor of the ras/extracellular signal-regulated kinase pathway in melanocytes and melanoma cells with wild-type BRAF but not with the V599E mutant. [electronic resource] - Cancer research Aug 2004 - 5556-9 p. digital

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.

0008-5472

10.1158/0008-5472.CAN-04-1669 doi


Cell Line, Tumor
Gene Expression Profiling
Humans
Intracellular Signaling Peptides and Proteins
MAP Kinase Signaling System--physiology
Melanocytes--enzymology
Melanoma--enzymology
Membrane Proteins
Mitogen-Activated Protein Kinases--antagonists & inhibitors
Mutation
Oligonucleotide Array Sequence Analysis
Protein Biosynthesis
Proteins--antagonists & inhibitors
Proto-Oncogene Proteins B-raf
Proto-Oncogene Proteins c-raf--genetics
RNA, Small Interfering--genetics
Transfection
ras Proteins--antagonists & inhibitors