Synthesis and biological evaluation of 3-heterocyclyl-7,8,9,10-tetrahydro-(7,10-ethano)-1,2,4-triazolo[3,4-a]phthalazines and analogues as subtype-selective inverse agonists for the GABA(A)alpha5 benzodiazepine binding site.

Street, Leslie J

Synthesis and biological evaluation of 3-heterocyclyl-7,8,9,10-tetrahydro-(7,10-ethano)-1,2,4-triazolo[3,4-a]phthalazines and analogues as subtype-selective inverse agonists for the GABA(A)alpha5 benzodiazepine binding site. [electronic resource] - Journal of medicinal chemistry Jul 2004 - 3642-57 p. digital

Publication Type: Journal Article

0022-2623

10.1021/jm0407613 doi


Administration, Oral
Animals
Binding Sites
Biological Availability
Cell Line
Female
GABA-A Receptor Agonists
Humans
Isoxazoles--chemical synthesis
Male
Maze Learning--drug effects
Oocytes--drug effects
Patch-Clamp Techniques
Phthalazines--chemical synthesis
Protein Subunits--agonists
Radioligand Assay
Rats
Structure-Activity Relationship
Triazoles--chemical synthesis
Xenopus laevis