Tamoxifen resistance by a conformational arrest of the estrogen receptor alpha after PKA activation in breast cancer.

Michalides, Rob

Tamoxifen resistance by a conformational arrest of the estrogen receptor alpha after PKA activation in breast cancer. [electronic resource] - Cancer cell Jun 2004 - 597-605 p. digital

Publication Type: Journal Article

1535-6108

10.1016/j.ccr.2004.05.016 doi


Antineoplastic Agents, Hormonal--pharmacology
Binding Sites
Blotting, Western
Breast Neoplasms--enzymology
Cell Division
Cell Line, Tumor
Cyclic AMP-Dependent Protein Kinases--metabolism
Down-Regulation
Drug Resistance, Neoplasm
Enzyme Activation
Enzyme Inhibitors--pharmacology
Estradiol--analogs & derivatives
Estrogen Receptor Modulators--pharmacology
Estrogen Receptor alpha
Female
Fluorescence Resonance Energy Transfer
Fulvestrant
Humans
Luciferases--metabolism
Microscopy, Confocal
Models, Biological
Nucleic Acid Hybridization
Oligonucleotide Array Sequence Analysis
Phosphorylation
Protein Conformation
Protein Structure, Tertiary
RNA Interference
Receptors, Estrogen--chemistry
Serine--chemistry
Tamoxifen--pharmacology
Time Factors
Transcriptional Activation
Transfection