Molecular modelling of the nucleotide-binding domain of Wilson's disease protein: location of the ATP-binding site, domain dynamics and potential effects of the major disease mutations.

Efremov, Roman G

Molecular modelling of the nucleotide-binding domain of Wilson's disease protein: location of the ATP-binding site, domain dynamics and potential effects of the major disease mutations. [electronic resource] - The Biochemical journal Aug 2004 - 293-305 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

1470-8728

10.1042/BJ20040326 doi


Adenosine Triphosphatases--chemistry
Adenosine Triphosphate--metabolism
Amino Acid Sequence--genetics
Binding Sites
Calcium-Transporting ATPases--metabolism
Cation Transport Proteins--chemistry
Circular Dichroism--methods
Computer Simulation
Copper-Transporting ATPases
Hepatolenticular Degeneration--genetics
Models, Molecular
Models, Structural
Molecular Sequence Data
Mutagenesis--genetics
Mutation--genetics
Nucleotides--metabolism
Peptides--chemistry
Protein Binding
Protein Structure, Tertiary