Discovery of novel 2,8-diazaspiro[4.5]decanes as orally active glycoprotein IIb-IIIa antagonists.

Mehrotra, Mukund M

Discovery of novel 2,8-diazaspiro[4.5]decanes as orally active glycoprotein IIb-IIIa antagonists. [electronic resource] - Journal of medicinal chemistry Apr 2004 - 2037-61 p. digital

Publication Type: Journal Article

0022-2623

10.1021/jm030354b doi


Administration, Oral
Alkanes--chemical synthesis
Animals
Aza Compounds--chemical synthesis
Binding, Competitive
Biological Availability
Bleeding Time
Dogs
Humans
Hydantoins--chemical synthesis
Hydroxylamines--chemical synthesis
In Vitro Techniques
Lactams--chemical synthesis
Macaca fascicularis
Mice
Platelet Aggregation Inhibitors--chemical synthesis
Platelet Glycoprotein GPIIb-IIIa Complex--antagonists & inhibitors
Prodrugs--chemical synthesis
Rats
Rats, Sprague-Dawley
Spiro Compounds--chemical synthesis
Structure-Activity Relationship
Urea--analogs & derivatives