Homocysteine increases the expression of vascular endothelial growth factor by a mechanism involving endoplasmic reticulum stress and transcription factor ATF4.

Roybal, C Nathaniel

Homocysteine increases the expression of vascular endothelial growth factor by a mechanism involving endoplasmic reticulum stress and transcription factor ATF4. [electronic resource] - The Journal of biological chemistry Apr 2004 - 14844-52 p. digital

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.

0021-9258

10.1074/jbc.M312948200 doi


Activating Transcription Factor 4
Blotting, Northern
Blotting, Western
CCAAT-Enhancer-Binding Proteins--metabolism
Carrier Proteins--metabolism
Cell Line
Cell Nucleus--metabolism
DNA, Complementary--metabolism
Dactinomycin--pharmacology
Dose-Response Relationship, Drug
Endoplasmic Reticulum--metabolism
Endoplasmic Reticulum Chaperone BiP
Enzyme-Linked Immunosorbent Assay
Epithelial Cells--cytology
Genes, Dominant
Heat-Shock Proteins
Homocysteine--chemistry
Humans
Molecular Chaperones
Mutation
Neovascularization, Pathologic
Nucleic Acid Synthesis Inhibitors--pharmacology
Phosphorylation
Promoter Regions, Genetic
Protein Binding
RNA, Messenger--metabolism
Reverse Transcriptase Polymerase Chain Reaction
Stress, Physiological
Time Factors
Transcription Factor CHOP
Transcription Factors--metabolism
Transcription, Genetic
Up-Regulation
Vascular Endothelial Growth Factor A--biosynthesis