Repression of mitogen-activated protein kinase (MAPK) phosphatase-1 by anthracyclines contributes to their antiapoptotic activation of p44/42-MAPK.

Small, George W

Repression of mitogen-activated protein kinase (MAPK) phosphatase-1 by anthracyclines contributes to their antiapoptotic activation of p44/42-MAPK. [electronic resource] - The Journal of pharmacology and experimental therapeutics Dec 2003 - 861-9 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0022-3565

10.1124/jpet.103.055806 doi


Animals
Anthracyclines--pharmacology
Apoptosis--drug effects
Blotting, Western
Breast Neoplasms--enzymology
Cell Line, Tumor
Clone Cells
Dual Specificity Phosphatase 1
Enzyme Activation--drug effects
Enzyme Inhibitors--pharmacology
Epithelial Cells--drug effects
Female
Fluorescent Antibody Technique
Gene Silencing--drug effects
Humans
Luciferases--biosynthesis
Mice
Mice, Knockout
Mitogen-Activated Protein Kinase 3
Mitogen-Activated Protein Kinases--metabolism
Phosphorylation
Promoter Regions, Genetic--drug effects
Protein Phosphatase 1
Protein Tyrosine Phosphatases--antagonists & inhibitors
RNA, Messenger--biosynthesis
Reverse Transcriptase Polymerase Chain Reaction
Signal Transduction--drug effects
Transcription, Genetic