Influence of a peptide linker on biodistribution and metabolism of antibody-conjugated benzyl-EDTA. Comparison of enzymatic digestion in vitro and in vivo.

Studer, M

Influence of a peptide linker on biodistribution and metabolism of antibody-conjugated benzyl-EDTA. Comparison of enzymatic digestion in vitro and in vivo. [electronic resource] - Bioconjugate chemistry - 424-9 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.

1043-1802

10.1021/bc00017a012 doi


Amino Acid Sequence
Animals
Antibodies, Monoclonal--metabolism
Cathepsin B--metabolism
Cathepsin D--metabolism
Chromatography, High Pressure Liquid
Cross-Linking Reagents--pharmacokinetics
Edetic Acid--analogs & derivatives
Endopeptidases--metabolism
Imidoesters--pharmacokinetics
Immunotoxins--metabolism
Indium Radioisotopes
Liver--enzymology
Mice
Molecular Sequence Data
Oligopeptides--metabolism
Structure-Activity Relationship
Tissue Distribution