Identification of C8-methylguanine in the hydrolysates of DNA from rats administered 1,2-dimethylhydrazine. Evidence for in vivo DNA alkylation by methyl radicals.

Netto, L E

Identification of C8-methylguanine in the hydrolysates of DNA from rats administered 1,2-dimethylhydrazine. Evidence for in vivo DNA alkylation by methyl radicals. [electronic resource] - The Journal of biological chemistry Oct 1992 - 21524-7 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

0021-9258


1,2-Dimethylhydrazine
Alkylation
Animals
Carcinogens--toxicity
Chromatography, High Pressure Liquid
Chromatography, Ion Exchange
Colon--chemistry
DNA--chemistry
Dimethylhydrazines--toxicity
Free Radicals
Guanine--analogs & derivatives
Liver--chemistry
Male
Rats
Rats, Sprague-Dawley
Rats, Wistar
Spectrometry, Mass, Fast Atom Bombardment
Spectrophotometry, Ultraviolet