Predictive value of comparative molecular field analysis modelling of naphthalene inhibition of human CYP2A6 and mouse CYP2A5 enzymes.

Asikainen, Arja

Predictive value of comparative molecular field analysis modelling of naphthalene inhibition of human CYP2A6 and mouse CYP2A5 enzymes. [electronic resource] - Toxicology in vitro : an international journal published in association with BIBRA Aug 2003 - 449-55 p. digital

Publication Type: Comparative Study; Journal Article

0887-2333

10.1016/s0887-2333(03)00065-1 doi


Animals
Aryl Hydrocarbon Hydroxylases--antagonists & inhibitors
Cytochrome P-450 CYP2A6
Cytochrome P450 Family 2
Enzyme Inhibitors--pharmacology
Female
Humans
Hydroxylation
Kinetics
Male
Mice
Mice, Inbred DBA
Microsomes, Liver--drug effects
Mixed Function Oxygenases--antagonists & inhibitors
Models, Biological
NADP--metabolism
Naphthalenes--pharmacology
Oxidation-Reduction
Predictive Value of Tests