2-Aminoethoxydiphenyl borate (2-APB) antagonises inositol 1,4,5-trisphosphate-induced calcium release, inhibits calcium pumps and has a use-dependent and slowly reversible action on store-operated calcium entry channels.

Peppiatt, Claire M

2-Aminoethoxydiphenyl borate (2-APB) antagonises inositol 1,4,5-trisphosphate-induced calcium release, inhibits calcium pumps and has a use-dependent and slowly reversible action on store-operated calcium entry channels. [electronic resource] - Cell calcium Jul 2003 - 97-108 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0143-4160

10.1016/s0143-4160(03)00026-5 doi


Boron Compounds--pharmacology
Calcium Channels--drug effects
Calcium Signaling--drug effects
Calcium-Transporting ATPases--antagonists & inhibitors
Cell Membrane--drug effects
Cell Membrane Permeability--drug effects
Dose-Response Relationship, Drug
Electric Stimulation
HeLa Cells
Humans
Inositol 1,4,5-Trisphosphate--antagonists & inhibitors
Inositol 1,4,5-Trisphosphate Receptors
Membrane Potentials--drug effects
Mitochondria--drug effects
Myocytes, Cardiac
Receptors, Cytoplasmic and Nuclear--antagonists & inhibitors