Depsipeptide (FR901228) inhibits proliferation and induces apoptosis in primary and metastatic human uveal melanoma cell lines.

Klisovic, Dino D

Depsipeptide (FR901228) inhibits proliferation and induces apoptosis in primary and metastatic human uveal melanoma cell lines. [electronic resource] - Investigative ophthalmology & visual science Jun 2003 - 2390-8 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0146-0404

10.1167/iovs.02-1052 doi


Antibiotics, Antineoplastic--pharmacology
Apoptosis--drug effects
Blotting, Western
Butyrates--pharmacology
Caspase 3
Caspases--metabolism
Cell Cycle Proteins--genetics
Cell Division--drug effects
Cyclin-Dependent Kinase Inhibitor p21
Cyclin-Dependent Kinase Inhibitor p27
Cyclins--genetics
Depsipeptides
Dose-Response Relationship, Drug
Enzyme Inhibitors--pharmacology
Fas Ligand Protein
Flow Cytometry
Histone Deacetylase Inhibitors
Humans
Hydroxamic Acids--pharmacology
Melanoma--genetics
Membrane Glycoproteins--genetics
Peptides, Cyclic--pharmacology
Proto-Oncogene Proteins--genetics
Proto-Oncogene Proteins c-bcl-2--genetics
RNA, Messenger--metabolism
Reverse Transcriptase Polymerase Chain Reaction
Tumor Cells, Cultured
Tumor Suppressor Proteins--genetics
Uveal Neoplasms--genetics
bcl-2-Associated X Protein
fas Receptor--genetics