Phosphorylation of threonine 10 on CKBBP1/SAG/ROC2/Rbx2 by protein kinase CKII promotes the degradation of IkappaBalpha and p27Kip1.

Kim, Yun-Sook

Phosphorylation of threonine 10 on CKBBP1/SAG/ROC2/Rbx2 by protein kinase CKII promotes the degradation of IkappaBalpha and p27Kip1. [electronic resource] - The Journal of biological chemistry Aug 2003 - 28462-9 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0021-9258

10.1074/jbc.M302584200 doi


Alanine
Casein Kinase II
Cell Cycle Proteins--metabolism
Cell Division
Cyclin-Dependent Kinase Inhibitor p27
Cysteine Endopeptidases--metabolism
Enzyme Inhibitors--pharmacology
G1 Phase
Gene Expression
Guanosine Triphosphate--pharmacology
HeLa Cells
Humans
I-kappa B Proteins--metabolism
Leupeptins--pharmacology
Multienzyme Complexes--antagonists & inhibitors
Mutagenesis, Site-Directed
NF-KappaB Inhibitor alpha
Phosphorylation
Proteasome Endopeptidase Complex
Protein Serine-Threonine Kinases--metabolism
RNA--metabolism
RNA-Binding Proteins--chemistry
S Phase
Structure-Activity Relationship
Threonine--metabolism
Transfection
Tumor Suppressor Proteins--metabolism
Ubiquitin-Protein Ligases