Impaired trafficking and activation of tumor necrosis factor-alpha-converting enzyme in cell mutants defective in protein ectodomain shedding.

Borroto, Aldo

Impaired trafficking and activation of tumor necrosis factor-alpha-converting enzyme in cell mutants defective in protein ectodomain shedding. [electronic resource] - The Journal of biological chemistry Jul 2003 - 25933-9 p. digital

Publication Type: Journal Article

0021-9258

10.1074/jbc.M301673200 doi


ADAM Proteins
ADAM17 Protein
Animals
Biotinylation
Blotting, Western
CHO Cells
Cell Line
Cricetinae
DNA, Complementary--metabolism
Endoplasmic Reticulum--metabolism
Enzyme Activation
Glycoproteins--chemistry
HeLa Cells
Humans
Metalloendopeptidases--metabolism
Microscopy, Confocal
Microscopy, Fluorescence
Molecular Sequence Data
Mutation
Precipitin Tests
Protein Structure, Tertiary
Protein Transport
Reverse Transcriptase Polymerase Chain Reaction
Transfection
Transforming Growth Factor alpha--metabolism
Tumor Cells, Cultured
Tumor Necrosis Factor-alpha--metabolism
Zinc--metabolism
alpha 1-Antitrypsin--metabolism