Dominant-negative suppression of HCN channels markedly reduces the native pacemaker current I(f) and undermines spontaneous beating of neonatal cardiomyocytes.

Er, Fikret

Dominant-negative suppression of HCN channels markedly reduces the native pacemaker current I(f) and undermines spontaneous beating of neonatal cardiomyocytes. [electronic resource] - Circulation Jan 2003 - 485-9 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1524-4539

10.1161/01.cir.0000045672.32920.cb doi


Adenoviridae--genetics
Animals
Animals, Newborn
Biological Clocks
CHO Cells
Cricetinae
Cyclic Nucleotide-Gated Cation Channels
Electric Conductivity
Genetic Vectors
Heart--physiology
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
Ion Channels--antagonists & inhibitors
Muscle Proteins--antagonists & inhibitors
Mutation
Myocardial Contraction
Patch-Clamp Techniques
Potassium Channels
Rats