Structure-activity relationships of 1,2,4-benzotriazine 1,4-dioxides as hypoxia-selective analogues of tirapazamine.

Hay, Michael P

Structure-activity relationships of 1,2,4-benzotriazine 1,4-dioxides as hypoxia-selective analogues of tirapazamine. [electronic resource] - Journal of medicinal chemistry Jan 2003 - 169-82 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

0022-2623

10.1021/jm020367+ doi


Animals
Antineoplastic Agents--chemical synthesis
Cell Division--drug effects
Cell Hypoxia--drug effects
Cyclic N-Oxides--chemical synthesis
Drug Screening Assays, Antitumor
Humans
Inhibitory Concentration 50
Mice
Oxidation-Reduction
Solubility
Structure-Activity Relationship
Tirapazamine
Triazines--chemical synthesis
Tumor Cells, Cultured