Flavopiridol and trastuzumab synergistically inhibit proliferation of breast cancer cells: association with selective cooperative inhibition of cyclin D1-dependent kinase and Akt signaling pathways.

Wu, Kongming

Flavopiridol and trastuzumab synergistically inhibit proliferation of breast cancer cells: association with selective cooperative inhibition of cyclin D1-dependent kinase and Akt signaling pathways. [electronic resource] - Molecular cancer therapeutics Jul 2002 - 695-706 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

1535-7163


Antibodies, Monoclonal--pharmacology
Antibodies, Monoclonal, Humanized
Antineoplastic Agents--pharmacology
Blotting, Western
Breast Neoplasms--drug therapy
Cell Cycle
Cell Division--drug effects
Cell Separation
Chromones--pharmacology
Cyclin D1--metabolism
Dose-Response Relationship, Drug
Enzyme Inhibitors--pharmacology
Flavonoids--pharmacology
Flow Cytometry
Humans
Mitogen-Activated Protein Kinases--metabolism
Morpholines--pharmacology
Piperidines--pharmacology
Protein Serine-Threonine Kinases
Proto-Oncogene Proteins--metabolism
Proto-Oncogene Proteins c-akt
S Phase
Signal Transduction
Time Factors
Transfection
Trastuzumab
Tumor Cells, Cultured