Local expression of C-type natriuretic peptide suppresses inflammation, eliminates shear stress-induced thrombosis, and prevents neointima formation through enhanced nitric oxide production in rabbit injured carotid arteries.

Qian, Jian-Yong

Local expression of C-type natriuretic peptide suppresses inflammation, eliminates shear stress-induced thrombosis, and prevents neointima formation through enhanced nitric oxide production in rabbit injured carotid arteries. [electronic resource] - Circulation research Nov 2002 - 1063-9 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1524-4571

10.1161/01.res.0000043631.25915.e6 doi


Adenoviridae--genetics
Animals
Blood Flow Velocity--drug effects
Carotid Arteries--drug effects
Carotid Artery Thrombosis--pathology
Disease Models, Animal
Enzyme Inhibitors--pharmacology
Genes, Reporter
Genetic Therapy
Genetic Vectors--administration & dosage
Humans
Inflammation--metabolism
Intercellular Adhesion Molecule-1--biosynthesis
Lipoproteins--biosynthesis
Macrophages--pathology
Male
Natriuretic Peptide, C-Type--biosynthesis
Nitric Oxide--biosynthesis
Rabbits
Rats
Rats, Wistar
Stress, Mechanical
Tunica Intima--drug effects
Vascular Cell Adhesion Molecule-1--biosynthesis
Vasoconstrictor Agents--pharmacology
beta-Galactosidase--biosynthesis