Regulation of the IRF-1 tumour modifier during the response to genotoxic stress involves an ATM-dependent signalling pathway.

Pamment, Jessica

Regulation of the IRF-1 tumour modifier during the response to genotoxic stress involves an ATM-dependent signalling pathway. [electronic resource] - Oncogene Nov 2002 - 7776-85 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0950-9232

10.1038/sj.onc.1205981 doi


Androstadienes--pharmacology
Ataxia Telangiectasia--genetics
Ataxia Telangiectasia Mutated Proteins
Cell Cycle Proteins
Cells, Cultured--metabolism
Cyclin-Dependent Kinase Inhibitor p21
Cyclins--physiology
Cycloheximide--pharmacology
DNA--drug effects
DNA Damage
DNA-Binding Proteins--biosynthesis
Enzyme Inhibitors--pharmacology
Etoposide--toxicity
Fibroblasts--metabolism
Gamma Rays--adverse effects
Genes, Reporter
Genes, p53
Humans
Interferon Regulatory Factor-1
Melanoma--pathology
Phosphatidylinositol 3-Kinases--physiology
Phosphoinositide-3 Kinase Inhibitors
Phosphoproteins--biosynthesis
Phosphorylation
Poly I-C--pharmacology
Protein Processing, Post-Translational
Protein Serine-Threonine Kinases--deficiency
Protein Synthesis Inhibitors--pharmacology
RNA, Messenger--biosynthesis
Recombinant Fusion Proteins--biosynthesis
Signal Transduction--physiology
Transcription, Genetic
Tumor Cells, Cultured--metabolism
Tumor Suppressor Protein p53--biosynthesis
Tumor Suppressor Proteins
Wortmannin